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Parallel Squared Technology Institute (PTI) is a non-profit research institute aiming to  catalyze a leap in protein analysis technology and use it to explore new biological frontiers. PTI supports open research and educational opportunities supporting rapid career development for scientists, engineers, and mathematicians.

Why? Protein dysfunctions directly cause many diseases, such as Alzheimer’s disease. Yet, proteins remain understudied because of technological hurdles.

How? To resolve these limitations, PTI will develop mass tags enabling a new framework for multiplexed protein analysis by mass spectrometry towards achieving 100-fold increase in throughput. Scientists at and collaborating with the institute will use these gains to directly investigate disease mechanisms and resolve problems that have proven intractable for decades. Our proof of principle technology and strategies are outlined at: parallelsq.org.

PTI’s new approach requires synergy between a diverse team of chemists, machine learning engineers, biologists and mass spectrometrists. Alzheimer’s disease and aging will be among the first focuses of this technology-driven research organization.

New career opportunities

Members of PTI will be supported with industry-level resources to lead research projects and disseminate their discoveries and innovations to the broader biomedical community through frequent publications, presentations, and submissions to public data portals. 

Responsibilities

• Lead biological projects related to proteomics of Alzheimer's disease.
• Collaborate with chemists, research associates, computational scientists and mass spectrometrists to leverage PTI's platform for protein barcoding for biological discovery.
• Work closely with experimental and computational scientists to collaboratively design experiments, analyze experimental data, and interpret results.
• Perform experiments with exceptional levels of competence, reproducibility and documentation following appropriate research practices, including excellent laboratory notebook practices.
• Prepare internal reports and manuscripts, and present results at internal or external scientific meetings as appropriate.

• PhD in biology (e.g. Bioengineering, Molecular Biology, Neurobiology) or a related field in science and/or engineering, or equivalent working experience and track record.
• Extensive experience with molecular biology laboratory technique, e.g. cell and tissue culture, optical microscopy, molecular cloning, quantitative PCR, immunohistochemistry, etc.
• Excellent communication skills, record keeping ability, and attention to detail.
• Excellent interpersonal and collaboration skills.

• Strong record of publications in peer-reviewed scientific journals.

• You have a strong desire and intrinsic motivation to work collaboratively and inclusively as part of an interdisciplinary team science effort.
• You are committed to the ethos of open science, and want to see your work transparently disseminated.
• You’re mission-driven, and are seeking an environment where you can take long-term risks on moonshot science, shielded from academic or for-profit incentives.
• You’re seeking a high-leverage, non-traditional opportunity to maximize the impact of your science, establishing relationships with key stakeholders in the neuroscience community.
• You understand, appreciate and are ready to tackle the significant experimental challenges related to scalable cellular barcoding of mammalian brains.

• An opportunity to change the world and work with some of the most talented and collaborative experts across scientific fields.
• Excellent medical, dental, and vision insurance through a PPO plan; parental leave.
• Generous time off + paid holidays.
• Wellness allowance for fitness and wellness activities.

Convergent Research aims to help fill a structural gap in today's R&D system. We enable fundamental research that requires unusual levels of scale and coordination yet is not rapidly monetizable by industry. We’re bringing together top talent from academia, industry, and startups to build a new model for innovative R&D. As an incubator within the Schmidt Futures Network, we identify high-impact scientific or technical research and development opportunities, ultimately defining and launching these projects as Focused Research Organizations.

Convergent Research, LLC is an Equal Employment Opportunity employer that proudly pursues and hires a diverse workforce. We do not make hiring or employment decisions on the basis of race, color, religion or religious belief, ethnic or national origin, nationality, sex, gender, gender-identity, sexual orientation, disability, age, military or veteran status, or any other characteristic protected by applicable local, state, or federal law or Company policy. We strive for a healthy and safe workplace and strictly prohibit harassment of any kind.

Cultivarium is a Convergent Research focused research organization with a mission to accelerate the adoption of new organisms for biotechnology. We are looking for experts who can contribute both individually and as part of a team to create tangible solutions for a ‘moonshot’ project. This is a great opportunity to be part of a close-knit, driven team of scientists and engineers that are building technological infrastructure for non-model microorganisms, to open new avenues for science, technology, medicine and agriculture.  

We are looking for a synthetic biologist to join our Molecular Libraries team. The successful candidate will develop and perform library-based screens to facilitate the genetic modification of non-model microbes. We’re searching for a candidate with extensive knowledge of synthetic biology, molecular biology and/or genome engineering. You will perform hands-on wet lab experimentation and work with computational biologists and automation specialists. This is a full-time experimental role and must be on-site.

Responsibilities

• Devise, implement and optimize high-throughput screens to solve major challenges in non-model microbe genetic engineering, such as: identifying functional genetic tools, avoiding restriction-modification systems and developing novel strain engineering methods.
• Perform cloning of genetic libraries using methods such as Golden Gate assembly, DNA synthesis and Gibson assembly.
• Develop and perform end-to-end assays from molecular tools development, to microorganism screening, through to NGS library preparation and/or fluorescence-activated cell sorting (FACS).
• Work in collaboration with internal specialists in computational biology, automation and next-generation sequencing.
• Leverage high-throughput technologies (laboratory automation, next-generation sequencing, oligonucleotide microarrays) to accelerate domestication of non-model microbes.
• Engage with the wider research community to identify key obstacles to the domestication and utilization of non-model microbes.
• Produce open-access materials, data reports and protocols to maximize the impact and reach of Cultivarium’s tools and resources.
• Maintain high standards of reproducible and rigorous science, with meticulous documentation.
• Prepare internal reports and manuscripts, and present results at internal or external scientific meetings as appropriate.
• Write protocols and SOPs for manual and automated experiments.
• Demonstrate a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.

• PhD in molecular biology, biochemistry, synthetic biology or a related field or equivalent working experience and track record.
• Passion for impactful research aligned with the Cultivarium mission.
• Extensive experience in the development and implementation of advanced genetic tools - such as genome editing, CRISPR systems, transposons and DNA assembly - with particular emphasis on the challenges associated with applying these tools in non-model microbes.
• An appetite to break new ground and take on a complex, multi-faceted challenge.
• Excellent communication skills, collaboration skills, record keeping ability and attention to detail.
• Ability to ensure quality experimental design and follow protocols.
• Comfortable with using and learning lab automation tools.
• Demonstrated ability to work independently and in a team environment.
• Strong quantitative and analytical skills, proclivity for reasoning from first principles.
• Creative thinking, problem-solving skills.
• Ability to work in a fast-paced environment, set priorities and meet deadlines and to adapt to changing projects and goals.
• Proficiency to stay up to date with new technologies/literature related to the field.
• Authorized to work in the U.S. without sponsorship.

• Industrial experience and/or significant postdoctoral experience.
• Extensive experience with high-throughput screening, lab automation, next generation sequencing or oligonucleotide microarrays.

• An opportunity to change the world and work with some of the smartest and the most talented experts from different fields
• Excellent medical, dental, and vision insurance through a PPO plan; parental leave
• Generous time off + paid holidays
• Wellness allowance for fitness and wellness activities

Convergent Research aims to help fill a structural gap in today's R&D system. We enable fundamental research that requires unusual levels of scale and coordination yet is not rapidly monetizable by industry. We’re bringing together top talent from academia, industry, and startups to build a new model for innovative R&D. As an incubator within the Schmidt Futures Network, we identify high-impact scientific or technical research and development opportunities, ultimately defining and launching these projects as Focused Research Organizations.

Convergent Research, LLC is an Equal Employment Opportunity employer that proudly pursues and hires a diverse workforce. We do not make hiring or employment decisions on the basis of race, color, religion or religious belief, ethnic or national origin, nationality, sex, gender, gender-identity, sexual orientation, disability, age, military or veteran status, or any other characteristic protected by applicable local, state, or federal law or Company policy. We strive for a healthy and safe workplace and strictly prohibit harassment of any kind.